This was a study of children ages 5-10 who were experiencing a recent onset of tics, and comparison children with Tourette syndrome or with no tics. The purpose of this research was to compare children who would go on to develop Tourette Syndrome with children whose tics would resolve.
Enrollment is now closed. Thank you to all our participants for making this study possible! If you are a past or current participant and have a question, please contact our research staff at 314-273-7575.
Former New Tics Participant?
Consider taking part in our LoTS study! Call Luis at 314-273-7575 for more information.
Results from the New Tics study
Summary of design and early results
Black KJ, Kim S, Schlaggar BL, Greene DJ. The New Tics study: A Novel Approach to Pathophysiology and Cause of Tic Disorders. J Psychiatr Brain Sci. 2020;5. doi: 10.20900/jpbs.20200012. PubMed PMID: 32587895; PubMed Central PMCID: PMC7316401.
Clinical findings
Grossen S, Arbuckle AL, Ueda K, Bihun EC, Song DY, Koller JM, Reiersen AM, Schlaggar BL, Greene DJ, Black KJ: We’ve all been wrong about Provisional Tic Disorder. Compr Psychiatry 2024; 134:152510. PMID: 38941871. PubMed Central PMCID: PMC11373539. doi: 10.1016/j.comppsych.2024.152510
Arbuckle AL, Bihun EC, Schlaggar BL, Black KJ: Functional tic-like presentations differ strikingly from Provisional Tic Disorder [version 2; peer review: 2 approved]. F1000Research 2022; 11:1566. PMID: 37224324. PubMed Central PMCID: PMC10186060. doi: 10.12688/f1000research.129252.2
Beeler P, Jensen NO, Kim S, Robichaux-Viehoever A, Schlaggar BL, Greene DJ, Black KJ, Chakrabarty RK. Fractality of tics as a quantitative assessment tool for Tourette syndrome. J R Soc Interface 2022; 19(187):20210742. doi: 10.1098/rsif.2021.0742. PubMed PMID: 35193387; PubMed Central PMCID: PMC8864347.
Black KJ. Case Report: DSM-5 misses an edge case in tic disorders nosology. F1000Res. 2020;9:505. doi: 10.12688/f1000research.23991.1.PubMed PMID: 32595960; PubMed Central PMCID: PMC7309051.
Kim S, Greene DJ, Reiersen AM, Robichaux-Viehoever A, Bihun EC, Koller JM, Acevedo H, Schlaggar BL, Black KJ. Exploring behavioral markers predicting one-year tic outcome in children with recent-onset tics. 2019 October. Available from: https://www.sciencedirect.com/science/article/pii/S089085671931603X. DOI: 10.1016/j.jaac.2019.08.146.
Tic Suppression in Children With Recent-Onset Tics Predicts 1-Year Tic Outcome. J Child Neurol. 2019 Oct;34(12):757-764. doi: 10.1177/0883073819855531. PubMed PMID: 31241402; PubMed Central PMCID: PMC6733613.
Provisional Tic Disorder is not so transient. Sci Rep. 2019 Mar 8; 9(1):3951. doi: 10.1038/s41598-019-40133-4. PubMed PMID: 30850688; PubMed Central PMCID: PMC6408476.
Greene DJ, Koller JM, Robichaux-Viehoever A, Bihun EC, Schlaggar BL, Black KJ. Reward enhances tic suppression in children within months of tic disorder onset. Dev Cogn Neurosci. 2015 Feb;11:65-74. doi: 10.1016/j.dcn.2014.08.005. PubMed PMID: 25220075; PubMed Central PMCID: PMC4323948.
Other research findings
Black KJ, Ding J, Grossen SC, Koller JM, Lilic A, Gonzalez LA, Hershey T, Greene DJ, Schlaggar BL. Cortical thickness in provisional and chronic tic disorder [preprint, v. 1.1]. Zenodo, 11 September 2024.
Che T, Kim S, Greene DJ, Heywood A, Ding J, Schlaggar BL, Black KJ, Wang L. Correlating clinical course with baseline subcortical shape in Provisional Tic Disorder. CNS Spectrums [in press]. Early preprint available here
Kim S, Greene DJ, D’Andrea CB, Bihun EC, Koller JM, O’Reilly B, Schlaggar BL, Black KJ. Hippocampal Volume in Provisional Tic Disorder Predicts Tic Severity at 12-Month Follow-up. J Clin Med. 2020 Jun 3;9(6). doi: 10.3390/jcm9061715. PubMed PMID: 32503289; PubMed Central PMCID: PMC7355974.
Selected reviews
Black KJ, Kim S, Yang NY, Greene DJ: Course of tic disorders over the lifespan. Curr Dev Disord Rep 2021; 8(2):121-132. PubMed Central PMCID: PMC8223879. DOI: 10.1007/s40474-021-00231‑3 . Preprint on OSF.io, DOI: 10.31219/osf.io/vehjr
Ueda K, Black KJ: A comprehensive review of tic disorders in children. J Clin Med 2021; 10(11):2479. PMCID: PMC8199885. DOI: 10.3390/jcm10112479
Black KJ, Black ER, Greene DJ, Schlaggar BL. Provisional Tic Disorder: What to tell parents when their child first starts ticcing. F1000Research. 2016; 5:696. PubMed PMID: 27158458, PMCID: PMC4850871. DOI: 10.12688/f1000research.8428.1
Tools
Black JK, Koller JM, Black KJ. TicTimer Web: software for measuring tic suppression remotely. F1000Res. 2020;9:1264. doi: 10.12688/f1000research.26347.2. PubMed PMID: 33824720; PubMed Central PMCID: PMC7993402.
Black JK, Koller JM, Black KJ. TicTimer software for measuring tic suppression. F1000Res. 2017;6:1560. doi: 10.12688/f1000research.12327.2. eCollection 2017. PubMed PMID: 29375812; PubMed Central PMCID: PMC5770993.