ENROLLMENT IS NOW CLOSED.
Thank you to all our participants for making this study possible! If you are a past or current participant and have a question, please contact our research staff at 314-273-7575.
Dr. Kevin Black, M.D., is conducting a study with children ages 5-10 who are experiencing a recent onset of tics, and other, control children. The purpose of this research is to compare children who go on to develop Tourette Syndrome with children whose tics will resolve.
Tics are repetitive, involuntary sounds or movements like eye blinking, sniffing, abdominal tensing or making small noises.
Many children with ADHD (20-50%) also have tics, even if they haven’t noticed them.
Children, ages 5-10, right-handed, who have been diagnosed with Tourette Syndrome or a Chronic Tic Disorder.
Children, ages 6-9, right or left handed, who have been diagnosed with ADHD but NOT Tourette Syndrome or a Chronic Tic Disorder.
Who may qualify for this study?
- Children ages 5-10 years old with parent/guardian participation
- Children with tics that started less than 12 months ago
- Children with Tourette syndrome or chronic tics
- Children without tics who have ADHD
What does participation include?
- Up to 6 visits, including annual follow-ups
- Compensated up to $100 per visit.
- MRI scans, interviews, questionnaires & DNA sample
- Study procedures are provided at no cost to you
Results from the New Tics study
Summary of design and early results
Black KJ, Kim S, Schlaggar BL, Greene DJ. The New Tics study: A Novel Approach to Pathophysiology and Cause of Tic Disorders. J Psychiatr Brain Sci. 2020;5. doi: 10.20900/jpbs.20200012. PubMed PMID: 32587895; PubMed Central PMCID: PMC7316401.
New Tics project publications: Data
Beeler P, Jensen NO, Kim S, Robichaux-Viehoever A, Schlaggar BL, Greene DJ, Black KJ, Chakrabarty RK. Fractality of tics as a quantitative assessment tool for Tourette syndrome. J R Soc Interface 2022; 19(187):20210742. doi: 10.1098/rsif.2021.0742. PubMed PMID: 35193387; PubMed Central PMCID: PMC8864347.
Kim S, Greene DJ, D’Andrea CB, Bihun EC, Koller JM, O’Reilly B, Schlaggar BL, Black KJ. Hippocampal Volume in Provisional Tic Disorder Predicts Tic Severity at 12-Month Follow-up. J Clin Med. 2020 Jun 3;9(6). doi: 10.3390/jcm9061715. PubMed PMID: 32503289; PubMed Central PMCID: PMC7355974.
Black KJ. Case Report: DSM-5 misses an edge case in tic disorders nosology. F1000Res. 2020;9:505. doi: 10.12688/f1000research.23991.1.PubMed PMID: 32595960; PubMed Central PMCID: PMC7309051.
Kim S, Greene DJ, Reiersen AM, Robichaux-Viehoever A, Bihun EC, Koller JM, Acevedo H, Schlaggar BL, Black KJ. Exploring behavioral markers predicting one-year tic outcome in children with recent-onset tics. 2019 October. Available from: https://www.sciencedirect.com/science/article/pii/S089085671931603X. DOI: 10.1016/j.jaac.2019.08.146.
Tic Suppression in Children With Recent-Onset Tics Predicts 1-Year Tic Outcome. J Child Neurol. 2019 Oct;34(12):757-764. doi: 10.1177/0883073819855531. PubMed PMID: 31241402; PubMed Central PMCID: PMC6733613.
Greene DJ, Koller JM, Robichaux-Viehoever A, Bihun EC, Schlaggar BL, Black KJ. Reward enhances tic suppression in children within months of tic disorder onset. Dev Cogn Neurosci. 2015 Feb;11:65-74. doi: 10.1016/j.dcn.2014.08.005. PubMed PMID: 25220075; PubMed Central PMCID: PMC4323948.
New Tics project publications: Selected reviews
Black KJ, Kim S, Yang NY, Greene DJ: Course of tic disorders over the lifespan. Curr Dev Disord Rep 2021; 8(2):121-132. PubMed Central PMCID: PMC8223879. DOI: 10.1007/s40474-021-00231‑3 . Preprint on OSF.io, DOI: 10.31219/osf.io/vehjr
Black KJ, Black ER, Greene DJ, Schlaggar BL. Provisional Tic Disorder: What to tell parents when their child first starts ticcing. F1000Research. 2016; 5:696. PubMed PMID: 27158458, PMCID: PMC4850871. DOI: 10.12688/f1000research.8428.1
New Tics project publications: Tools
Black JK, Koller JM, Black KJ. TicTimer Web: software for measuring tic suppression remotely. F1000Res. 2020;9:1264. doi: 10.12688/f1000research.26347.2. PubMed PMID: 33824720; PubMed Central PMCID: PMC7993402.
Black JK, Koller JM, Black KJ. TicTimer software for measuring tic suppression. F1000Res. 2017;6:1560. doi: 10.12688/f1000research.12327.2. eCollection 2017. PubMed PMID: 29375812; PubMed Central PMCID: PMC5770993.