Cannabidiol and the DEA

The US FDA approved Epidiolex® (cannabidiol, or CBD) for certain seizure syndromes in June, 2018, and in November, 2018, the DEA rescheduled it as a Schedule V controlled substance (the least restrictive). This will greatly facilitate clinical use and clinical trials of CBD in the U.S. Note that there is little evidence at this point […]

Can median nerve stimulation reduce tics?

A fascinating publication from the University of Nottingham describes a non-invasive method that may reduce tics. The idea is that rhythmic input to a brain region can entrain that region to fire in synchrony with the input, and some rhythmic firing patterns seem to inhibit movement. The stimulation was delivered by generating a small electrical […]

Disappointing results from VMAT2 inhibitors

Teva Pharmaceuticals recently announced that in a couple of studies, deutetrabenazine did not prove statistically superior to placebo for treatment of Tourette syndrome in youth.* This  honestly comes as a big surprise to me (and of course to the sponsor). Although without controlled trial evidence, its parent drug tetrabenazine had been used for tics for […]

TAA statement on PANDAS

The Tourette Association of America’s PANDAS/PANS Workgroup has issued a public statement about PANDAS. It succinctly summarizes the current state of evidence about this controversial diagnosis. A recommended read for anyone interested.

Tic Talk 2020 initial survey results

Below is a brief summary of the results from the first 21 people to take the survey. If you haven’t already responded, we’d love your input to help us design Tic Talk 2020 by taking this short 5-question survey: Topics you are interested in: Tics and school: 76% How psychological factors or situations influence tics: […]

Help us plan content for Tic Talk 2020

Tic Talk 2020 is on! Saturday, May 2, 2020, at Wash. U. School of Medicine. We want to hear from you about what topics we should cover. Please take this short 5-question survey: Thank you!

Safety of antipsychotic medications

A new publication reports on antipsychotic medications in people with schizophrenia. Of course schizophrenia is very different from tic disorders. Nevertheless, the medications best proven to reduce tic severity are also used as antipsychotics. In both populations concerns arise about the long-term impacts of physical side effects of antipsychotics, especially with regards to obesity and […]

“I’ve found the answer to TS,” or why science isn’t faster

Recently someone with TS wrote me to say that he had discovered a trigger for tics and a potential treatment that might apply to others. I applaud his careful observations and willingness to share. But how can we move this observation forward? After all, numerous potential cures to TS have been proposed, ranging from antibiotics […]

Treating tics: an overview

What can I do for my child with tics? The first question is whether s/he needs treatment. Most children probably don’t. All of our current treatments just reduce the symptoms. A key question is, are the tics really interfering (now) with schoolwork or friendship, or interfering with other students’ learning? If so, then that’s a […]